The brain’s ability to grow and form new connections typically declines with age, which may explain why mental functioning gets worse in many older adults (1).
Studies have found that lion’s mane mushrooms contain two special compounds that can stimulate the growth of brain cells: hericenones and erinacines (2).
Additionally, animal studies have found that lion’s mane may help protect against Alzheimer’s disease, a degenerative brain disease that causes progressive memory loss.
In fact, lion’s mane mushroom and its extracts have been shown to reduce symptoms of memory loss in mice, as well as prevent neuronal damage caused by amyloid-beta plaques, which accumulate in the brain during Alzheimer’s disease ( 3 , 4, 5 , 6).
While no studies have analyzed whether lion’s mane mushroom is beneficial for Alzheimer’s disease in humans, it appears to boost mental functioning.
A study in older adults with mild cognitive impairment found that consuming 3 grams of powdered lion’s mane mushroom daily for four months significantly improved mental functioning, but these benefits disappeared when supplementation stopped (7).
The ability of lion’s mane mushroom to promote nerve growth and protect the brain from Alzheimer’s-related damage may explain some of its beneficial effects on brain health.
However, it’s important to note that most of the research has been conducted in animals or in test tubes. Therefore, more human studies are needed.
Lion’s mane mushrooms contain compounds that stimulate the growth of brain cells and protect them from damage caused by Alzheimer’s disease. However, more human research is needed.
2. Helps Relieve Mild Symptoms of Depression and Anxiety
Up to one-third of people living in developed countries experience symptoms of anxiety and depression (8).
While there are many causes of anxiety and depression, chronic inflammation could be a major contributing factor.
New animal research has found that lion’s mane mushroom extract has anti-inflammatory effects that canreduce symptoms of anxietyand depression in mice ( 9 ,10).
Other animal studies have found that lion’s mane extract can also help regenerate brain cells and improve the functioning of the hippocampus, a region of the brain responsible for processing memories and emotional responses (11 ,12).
Researchers believe that improved functioning of the hippocampus may explain the reductions in anxious and depressive behaviors in mice given these extracts.
While these animal studies are promising, there is very little research in humans.
One small study in menopausal women found that eating cookies containing lion’s mane mushrooms daily for one month helped reduce self-reported feelings of irritation and anxiety (13 ).
Studies suggest that lion’s mane mushrooms may help relieve mild symptoms of anxiety and depression, but more human research is needed to better understand the correlation.
3. May Speed Recovery from Nervous System Injuries
The nervous system consists of the brain, spinal cord and other nerves that travel throughout the body. These components work together to send and transmit signals that control almost every bodily function.
Injuries to the brain or spinal cord can be devastating. They often cause paralysis or loss of mental functions and can take a long time to heal.
However, research has found that lion’s mane mushroom extract may help speed recovery from these types of injuries by stimulating the growth and repair of nerve cells (14 ,15 ,16 ).
In fact, lion’s mane mushroom extract has been shown to reduce recovery time by 23–41% when given to rats with nervous system injuries (17).
Lion’s mane extract may also help reduce the severity of brain damage after a stroke.
In one study, high doses of lion’s mane mushroom extract given to rats immediately after a stroke helped decrease inflammation and reduce the size of stroke-related brain injury by 44% (18).
While these results are promising, no studies have been conducted in humans to determine if lion’s mane would have the same therapeutic effect on nervous system injuries.
Rat studies have found that lion’s mane extract can speed up recovery time from nervous system injuries, but human research is lacking.
Ulcers are capable of forming anywhere along the digestive tract, including the stomach, small intestine and large intestine.
Stomach ulcersare often caused by two major factors: overgrowth of a bacteria calledH. pyloriand damage to the mucous layer of the stomach that’s often due to long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) (19).
Lion’s mane extract may protect against the development of stomach ulcers by inhibiting the growth ofH. pyloriand protecting the stomach lining from damage (20 ,21).
Several studies have found that lion’s mane extract can prevent the growth ofH. pyloriin a test tube, but no studies have tested whether they have the same effects inside the stomach (22 ,23 ).
Additionally, an animal study found that lion’s mane extract was more effective at preventing alcohol-induced stomach ulcers than traditional acid-lowering drugs — and without any negative side effects (24).
Lion’s mane extract can also reduce inflammation and prevent tissue damage in other areas of the intestines. In fact, they may help treat inflammatory bowel diseases likeulcerative colitisandCrohn’s disease(25,26,27).
One study in people with ulcerative colitis found that taking a mushroom supplement containing 14% lion’s mane extract significantly reduced symptoms and improved quality of life after three weeks (28).
However, when the same study was repeated in patients with Crohn’s disease, the benefits were no better than a placebo (29).
It’s important to note that the herbal supplement used in these studies included several types of mushrooms, so it’s difficult to draw any conclusions about the effects of lion’s mane specifically.
Overall, research suggests that lion’s mane extract may help inhibit the development of ulcers, but more human research is needed.
Lion’s mane extract has been shown to protect against stomach and intestinal ulcers in rodents, but human research has been conflicting.
5. Reduces Heart Disease Risk
Major risk factors for heart disease include obesity, high triglycerides, large amounts of oxidized cholesterol and an increased tendency to get blood clots.
Research shows that lion’s mane extract can influence some of these factors and reduce the risk of heart disease.
Studies in rats and mice have found that lion’s mane mushroom extract improves fat metabolism and lowers triglyceride levels (30).
One study in rats fed a high-fat diet and given daily doses of lion’s mane extract observed 27% lower triglyceride levels and 42% less weight gain after 28 days (31).
Since obesity and high triglycerides are both considered risk factors for heart disease, this is one way that lion’s mane mushrooms contribute to heart health.
Test-tube studies have also found that lion’s mane extract can help prevent the oxidation of cholesterol in the bloodstream (32).
Oxidized cholesterol molecules tend to attach to the walls of arteries, causing them to harden and increasing the risk of heart attack and stroke. Therefore, reducing oxidation is beneficial for heart health.
What’s more, lion’s mane mushrooms contain a compound called hericenone B, which can decrease the rate of blood clotting and lower the risk of heart attack or stroke (33).
Lion’s mane mushrooms appear to benefit the heart and blood vessels in multiple ways, but human studies are needed to support this.
Animal and test-tube studies suggest that lion’s mane extract can reduce the risk of heart disease in several ways, but human studies are needed to confirm these findings.